Select the most appropriate option to fill in the blank. He is _________ tired to finish his homework.

Explanation

The sentence should be read as: “He is too tired to finish his homework.” The word “too” means excessively or very, which fits the context of being so tired that he cannot complete his homework. The other options are incorrect: (1) “to” is a preposition and does not fit here, (3) “most” means the greatest in amount or degree and does not make sense in this context, and (4) “more” indicates an additional amount and does not work in this sentence.